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Phospholipids for injectable drug depots: Where do we stand?
PRC Online Seminar Professor Dr. Paola Luciani - University of Bern, Switzerland

By direct deposition of the drug at the site of action, injectable depot formulations enable to limit the immediate exposure of the active principle at a systemic level and to reduce the frequency of administration. Typically, small molecules and peptides have been successfully loaded in preformed implants, in situ forming implants, microspheres, and injectable depots. Biodegradable polymers and lipids are the constituents of choice for single-procedure injectable depot systems, being both highly biocompatible and susceptible to hydrolytic degradation under physiological conditions. In this seminar we aim to give an overview of the recent advances in the field of phospholipid-based injectable depots, and to critically discuss limitations and challenges inherent in this technology.
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