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Proteoform Thursday: Caroline DeHart presents "Top-Down Mass Spectrometry Reveals an Expanded RAS Proteoform Landscape in Malignant Cell Lines"
The RAS family of GTPases (HRAS, KRAS4A, KRAS4B, NRAS) are among the most commonly mutated oncogenes in human cancer and present a formidable challenge to standard proteomic workflows. Targeted top-down proteomic analysis can provide an entirely new perspective on oncogenic RAS proteoforms, revealing novel post-translational modifications and surprising insights about the nature of RAS-dependent signaling. Caroline will discuss the progress of several ongoing efforts to improve the characterization of endogenous RAS proteoforms within malignant cell lines, with the end goals of better understanding and inhibiting RAS-dependent oncogenesis.

Dr. Caroline DeHart
Dr. DeHart received a B.S. in Biochemistry & Molecular Biology from the University of Maryland, Baltimore County, as an M16 in the Meyerhoff Scholarship Program. She received an M.A. and Ph.D. in Molecular Biology from Princeton University under the mentorship of S. Jane Flint, followed by postdoctoral training in the laboratories of Neil L. Kelleher at Northwestern University and Christopher L. Hendrickson at the National High Magnetic Field Laboratory. Dr. DeHart subsequently served as the Director of Outreach and Training, then Director of Cancer Proteomics for the National Resource for Translational and Developmental Proteomics (NRTDP) at Northwestern University, while achieving the rank of Research Assistant Professor in the Dept. of Molecular Biosciences. Dr. DeHart is currently a Principal Investigator and the Mass Spectrometry Group Leader for the National Cancer Institute (NCI) RAS Initiative at the Frederick National Laboratory for Cancer Research.

Nov 17, 2022 11:00 AM in Eastern Time (US and Canada)

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