We are delighted to have Burkhard Becher, Professor at the Institute of Experimental Immunology at the University of Zurich, as our guest in our next Scientist in the Spotlight.
While T cells are generally thought of as mediators of tissue damage in chronic tissue inflammation, the cellular infiltrate is always dominated by myeloid cells. The granulocyte-macrophage colony-stimulating factor (GM-CSF) serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. The pivotal role of GM-CSF at the T-cell:myeloid cell interface might shift our attention toward studying the function of the myeloid compartment in immunopathology and targeting specifically the crosstalk between T cells and myeloid cells through GM-CSF.
In this webinar learn how GM-CSF licenses phagocytes to initiate tissue damage in chronic inflammatory diseases and about new tools for tracing and fate-mapping of GM-CSF expressing cells and their role in tissue inflammation in vivo.