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Tissue-invading phagocytes: mediators of immunopathology in chronic inflammation
We are delighted to have Burkhard Becher, Professor at the Institute of Experimental Immunology at the University of Zurich, as our guest in our next Scientist in the Spotlight.

While T cells are generally thought of as mediators of tissue damage in chronic tissue inflammation, the cellular infiltrate is always dominated by myeloid cells. The granulocyte-macrophage colony-stimulating factor (GM-CSF) serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. The pivotal role of GM-CSF at the T-cell:myeloid cell interface might shift our attention toward studying the function of the myeloid compartment in immunopathology and targeting specifically the crosstalk between T cells and myeloid cells through GM-CSF. 

In this webinar learn how GM-CSF licenses phagocytes to initiate tissue damage in chronic inflammatory diseases and about new tools for tracing and fate-mapping of GM-CSF expressing cells and their role in tissue inflammation in vivo.


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