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High-resolution mass spectrometry of oligonucleotides – characterization made easy
In this webinar we will present direct, robust and easy-to-use techniques to fully characterize the nucleotide sequence of highly modified single-stranded RNAs by top down tandem MS. This will include a case study for a N-acetylgalactosamine modified RNA sense strand. The approach can be applied on a single strand level, as well as on siRNA duplex level in a single electrospray ionization MS (ESI-MS) experiment. This procedure also allows us to reliably predict the structure of impurities that can occur during oligonucleotide production, which supports process improvements in manufacturing.

Giovanni Calderisi
Project Chemist QC at Bachem AG

Naoki Yamamoto
Head of Business Development & Sales, Asia Pacific at Bachem Japan

Date: Thursday, December 15th
Time: 8am CET / 4PM JST

Dec 12, 2022 09:00 AM in Zurich

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Giovanni Calderisi
Project Chemist QC @Bachem AG
Giovanni joined Bachem in Bubendorf (Switzerland) in September 2020 as an expert in mass spectrometry of oligonucleotides. In his current position as a project chemist he is responsible for establishing routine workflows for characterization of oligonucleotides and peptides by ultra-high resolution mass spectrometry. Giovanni holds a Ph.D. in chemistry with focus on biomolecular mass spectrometry at the University of Innsbruck, Austria.
Naoki Yamamoto, Ph.D.
Head of Business Development & Sales, Asia Pacific @Bachem Japan
Naoki Yamamoto is Head of Business Development & Sales, Asia Pacific at Bachem Japan since Jan 2022. For the past 16 years, he’s been involved in the development of new synthetic methodologies for glycopeptides and glycoproteins, purification & analytical technologies for those materials, and coordinating several collaborations and alliances with not only domestic pharma companies but also international pharms. Prior to joining Bachem Japan, he was RAQA & BD Director at 3-D Matrix (2017-2021), and a regional president at Brand Institute (2015-2016). Prior to Brand Institute, he was served as a Senior Investigator at GlyTech (2012-2014) and American Peptide Company, Sunnyvale, California in the US (2009-2012). Prior to American Peptide Company, he was a Researcher at Otsuka Chemical Company (2006-2009). He received his Ph.D. degree in Chemistry from Yokohama City University, Japan in 2006.