In this webinar we will present direct, robust and easy-to-use techniques to fully characterize the nucleotide sequence of highly modified single-stranded RNAs by top down tandem MS. This will include a case study for a N-acetylgalactosamine modified RNA sense strand. The approach can be applied on a single strand level, as well as on siRNA duplex level in a single electrospray ionization MS (ESI-MS) experiment. This procedure also allows us to reliably predict the structure of impurities that can occur during oligonucleotide production, which supports process improvements in manufacturing.
Project Chemist QC at Bachem AG
Head of Business Development & Sales, Asia Pacific at Bachem Japan
Date: Thursday, December 15th
Time: 8am CET / 4PM JST