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Spatial and Phenotypic Mapping of Immune Cell Infiltration in Type 1 Diabetes
We are delighted to have Nicolas Damond from the Department of Quantitative Biomedicine at the University of Zurich and the Institute of Molecular Health Sciences at ETH Zurich as our next Scientist in the Spotlight.

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing pancreatic beta cells. A comprehensive picture of the changes that occur in the human pancreas during T1D progression is lacking, in part due to limited sample availability.  By measuring cell phenotypes and functions in their spatial context, Imaging Mass Cytometry provides a precise picture of the tissue ecosystem for each analyzed sample.

Join this webinar to learn the value of high-plex imaging for improving our understanding of T1D pathogenesis and and for studying a wide range of other diseases.

01:03:00

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Speakers

Nicolas Damond
@University of Zurich
I did my PhD with Prof. Pedro Herrera at the University of Geneva, studying regeneration of insulin-producing beta cells by transdifferentiation of the closely related alpha cells. During my thesis, I used confocal microscopy and lineage tracing in complex transgenic mouse models and primary human pancreatic islets. This work sparked my interest into both T1D research and image analysis of single cells, two elements that are still at the center of my current projects. In the Bodenmiller lab, I use imaging mass cytometry to analyze pancreas sections of individuals with or at risk for type 1 diabetes. The multiplexing capacity of this technology enables deep phenotyping of beta cells and of infiltrating immune cells, and mapping of their interactions. The goal of this project is to gain a better understanding of T1D development in the pancreas.