The administration of a high fraction of oxygen following the return of spontaneous circulation in out-of-hospital cardiac arrest may increase reperfusion brain injury. Join us at the next PCRF Journal Club as we review a study that evaluated whether targeting a lower oxygen saturation in the early phase of post-resuscitation care for out-of-hospital cardiac arrest improves survival at hospital discharge.
Article: Bernard SA, Bray JE, Smith K, Stephenson M, Finn J, Grantham H, Hein C, Masters S, Stub D, Perkins GD, Dodge N, Martin C, Hopkins S, Cameron P; EXACT Investigators. Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial. JAMA. 2022 Oct 26. doi: 10.1001/jama.2022.17701. Epub ahead of print. PMID: 36286192.