The healthcare landscape across the world is on a transformational journey which is likely to accelerate recognizing the significant lessons from the COVID -19 pandemic. Many healthcare organizations are rethinking their business model and value differentiation. We can expect analytics, digital technology, consumerism and value-driven care to play a greater role in the delivery of care especially with the growth of telemedicine, hospital-at-home initiatives, and remote patient monitoring devices. Mayo Clinic has a rich legacy and culture of using analytics, operations research, technology and management engineering for sustained excellence in clinical care, research, education and operations. This session will highlight the strategic priorities, novel application, learning journey and key success factors related to leveraging analytics to deliver patient focused healthcare.