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Pathology Grand Rounds October 2021- Sponsored by PathSoc & The Jean Shanks Foundation
Title: Mapping spatial heterogeneity in cancers to understand diverse disease outcomes

Dr Anita Grigoriadis, King's College London and Dr Lucy Yates, Wellcome Sanger Institute, Cambridge

Breast cancers are complex ecosystems composed of diverse neoplastic, stromal and immune populations. The interaction between cancer cells and their tumour microenvironment (TME) is a critical determinant of clinical outcome. The emergence of spatial technologies such as digital pathology and spatial transcriptomics opens up the possibility for a wide range of critical scientific questions to be addressed in actual patient samples.

The two talks at this Pathological Society grand round will provide insights into two approaches that use spatial information to understand cancer outcomes. In the first talk, Dr Anita Grigoriadis illustrates how morphological features in lymph nodes can be captured and quantified by deep learning approaches using digitised whole slide images, and demonstrates that these features even in cancer-free lymph nodes carry prognostic relevance for high-risk triple negative breast cancer patients. In the second talk, Dr Lucy Yates, describes how she is building genetic cancer clone maps to understand how individual subclones interact with the TME and how this shapes cancer evolution.

Oct 13, 2021 09:00 AM in London

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Dr Anita Grigoriadis
Non-Clinical Deputy Head for the Breast Cancer Now Unit @King's College London
Anita Grigoriadis is the Non-Clinical Deputy Head for the Breast Cancer Now Unit, and a Reader in Cancer Bioinformatics at King’s College London, London UK. After finishing her degree at the Institute of Molecular Pathology, University of Vienna (Austria), Anita pursued a joint PhD between the Ludwig Institute for Cancer Research, London UK and Faculty of Natural Sciences, Salzburg Austria. Anita conducted her postdoctoral training on breast cancer genomics with Professor Alan Ashworth at Breakthrough Breast Cancer Centre (London). In 2008, she joined the Breast Cancer NOW Unit (formerly Breakthrough Breast Cancer Research) at King’s under the leadership of Professor Andrew Tutt, and started her own team in 2013. Currently, Anita is a committee member of the CRUK City of London Centre Executive Board, The Clinical Trial Pathology Advisory Group of the Cellular Molecular Pathology (NCRI programme), and recently the Research Subcommittee of the Pathological Society.
Professor Mark Arends
@University College of London
The session will be chaired by Professor Mark Arends who is the President of the Pathological Society of Great Britain and Ireland.
Dr Lucy Yates
Clinical Career Development Fellow at the Wellcome Sanger Institute @Wellcome Sanger Institute, Cambridge
Lucy Yates is a Clinical Career Development Fellow at the Wellcome Sanger Institute. Lucy trained as a clinical oncologist in London, UK and attained a PhD in cancer genomics and evolution from the Wellcome Sanger Institute and the University of Cambridge. Her research program is focused on understanding the evolutionary mechanisms underlying cancer onset, growth and progression. This is achieved by employing a range of genomic and spatial profiling techniques and developing computational approaches that facilitate the integration and modelling of multi-layered datasets.