Leading experts will introduce the audience to recent advances in decoding the specific T cell or B cell clonotypes mediating or protecting from disease along with their recognized antigen epitopes in the context of human HLA haplotypes. This information promises to enable next generation clonotype or epitope targeted immunotherapies for cancer, autoimmune or infectious diseases that are both more efficacious and safer than current therapies. Recent advances in single cell sequencing technologies and large-scale HLA tetramer or HLA reporter gene-based epitope library screening technologies have made decoding the "immune synapse" possible. Additional speakers will discuss how they are developing powerful immunotherapies based on decoded immune repertoires.
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