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FASEB Catalyst Conference: Adipose Tissue Transduces Dysbiosis to Heart Disease: An Avenue to Novel Therapies

A considerable health burden is associated with metabolic impairment due to the high risk of cardiovascular mortality and morbidity. Metabolic impairment has long been recognized to induce a state of chronic low-grade inflammation, triggering cardiovascular dysfunction. In the same context, diet remains a main modulator of colonic microbiota with western-type, calorie-dense diets driving an imbalance of microorganisms in the gut known as dysbiosis. A major challenge in cardiometabolic disease management is that the deleterious pathological process appears to start much earlier than the initial diagnostic markers of metabolic impairment such as hyperglycemia and overt increases in adiposity. Recent research implicated localized inflammatory changes in select adipose depots as a driver of the earliest pathological transformation in cardiovascular tissues/organs in prediabetes without systemic involvement. Importantly, dysbiosis was suggested to augment the inflammatory phenotype in adipose tissue, increasing the risk of cardiovascular disease.

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FASEB is committed to sustaining diversity, equity, accessibility, and inclusion in the biological and biomedical sciences. FASEB’s goal is to create and support a conference environment that is welcoming and safe for all. FASEB believes inclusion of diverse participants, including attendees and speakers, is critical to the scientific and educational integrity of conferences. Organizers are expected to design programs that reflect this commitment. As part of FASEB’s ongoing assessment towards reaching its diversity goals, conference participants are asked to share diversity information. Any data collected from individuals is treated confidentially and used in aggregate format for internal and external review. For more information, please visit https://www.faseb.org/diversity-equity-and-inclusion

Jan 18, 2023 11:00 AM in Eastern Time (US and Canada)