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Career Options in Science – Industry
Sponsored by the ASIP Pathology in Biotech and Industry SIG

Image Analysis in IBD
Alexis Scherl, MD, PhD

Abstract: While numerous histologic scoring systems for Ulcerative Colitis disease activity have been developed, they are difficult to reliably implement, and are subject to inter- and inter-pathologist variability. A robust, reproducible, and high-throughput image analysis algorithm for scoring tissue biopsies would be highly desirable in a clinical trial context. In a translational research context, image analysis can provide in-depth characterization of the content of and spatial relationships between cells and tissue features within biopsies; this data can be leveraged to test specific hypotheses or for biomarker discovery.

Use of Mass Spectrometry to Localize and Quantify Test Articles in Tissue Sections
Shawn O'Neil, DVM, PhD

Abstract: Mass spectrometry (MS) provides a label-free method for identifying molecules in tissues based upon their chemical signature rather than using indirect approaches, such as IHC and ISH which rely on antibodies and molecular probes, respectively. In toxicologic pathology, MS methods are being developed to localize and measure test articles and their metabolites in tissues and to correlate these spatially with microscopic findings in tissue sections. This presentation will provide fundamental descriptions of spatial applications of MS technology, including MALDI mass spectrometry imaging (MALDI-MSI) as well as the combined use of laser capture microdissection (LCM) with conventional mass spec analysis (LCMS) as an alternative method that provides identification and quantification of molecules with limited spatial context.

Jul 13, 2022 12:00 PM in Eastern Time (US and Canada)

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Alexis Scherl, MD, PhD
Principal Scientist @Genentech
Alexis Scherl is a Principal Scientist in the Research Pathology Department at Genentech. Dr. Scherl completed her MD and Ph.D. degrees through the Medical Scientist Training Program at Albert Einstein College of Medicine, followed by a residency in anatomic pathology at Weill-Cornell Medical Center and an ACGME-certified gastrointestinal/liver pathology fellowship at Yale University School of Medicine. Since joining Genentech in 2014, Alexis has supported the GastroImmunology pipeline, including the assessment of pre-clinical models of inflammatory bowel disease and non-alcoholic steatohepatitis, the development and implementation of histologic endpoints for clinical trials, and the validation of companion diagnostic assays. She leads the Human Tissue Lab biobank and is the Research Pathology machine learning lead for non-oncology indications.
Shawn O'Neil, DVM PhD
Veterinary Pathologist/Senior Director in Drug Safety Research & Development @Pfizer
Shawn O’Neil is a veterinary pathologist and a Senior Director in Drug Safety Research & Development at Pfizer. He received a Veterinary Medical Degree (DVM) from Cornell University and completed a residency in Veterinary Anatomic Pathology and received a PhD in Pathology from the College of Veterinary Medicine & Biomedical Sciences at Colorado State University in Fort Collins, CO. Before joining Pfizer, Shawn was a Research Assistant Professor at Emory University and Director of the Molecular Pathology Core at Yerkes National Primate Research Center in Atlanta. He later served as Assistant Professor of Pathology and Chair of the Division of Comparative Pathology at Harvard Medical School and the New England Primate Research Center. Shawn joined Pfizer in 2008 and currently serves as Global Investigative Pathology Lead for Pfizer Global Pathology in Cambridge, MA.