Research integrity (RI) is a global problem that erodes the quality of research and the trustworthiness of researchers. Over a decade after the first World Conference in Research Integrity, very little has been done to create awareness of and establish necessary structures to promote responsible conduct of research in Africa. Research ethics (RE) has on the other hand has recorded a significant increase in awareness and practice. This webinar aims at examining the major challenges in advancing these ideals in Africa. The COVID-19 presents unique challenges that must be taken into consideration in the current discourse. Common examples of research ethics and research integrity challenges and practices from a Pan African Medical Journal perspective, as a major publisher are presented.